Postdoctoral Scientist - Devkota Lab - Inflammatory Bowel Disease Institute

Company: Cedars-Sinai
Location: Beverly Hills
Posted on: March 7, 2023

Job Description:

With your help, we can change the future of healthcare!

Cedars-Sinai Medical Center is an organization known nationally for excellence in Inflammatory Bowel Disease treatment, research, and education. Our Inflammatory Bowel Disease Institute (IBDI) is searching for a highly motivated Research Postdoctoral Scientist. We invite you to consider this exciting opportunity and provide us with an opportunity to learn more about you and your skills!

The Devkota Lab studies human health and disease through the trillions of bacteria that live in our gut. These bacteria not only make up more than half the cellular composition of the human body, they also generate a vast array of byproducts that serve as currencies for the exchange of information between our body and the outside world.

Of all the external factors that can influence the trading between bacteria and human cells, the amino acids, sugars, fatty acids, and fibers that make up our diet are the most ubiquitous and potent. The emergent patterns of microbial growth and productivity reveal both novel, and long-evolved relationships between host and microbe that can be leveraged for health.

Our goal is to define the mechanistic underpinnings of diet's extraordinary impact on the gut microbiome and translate these findings into prospective human studies in patients suffering from inflammatory and metabolic diseases in order to add a powerful dimension to the diagnosis and treatment of inflammatory bowel diseases (IBDs), diabetes, and cancer.

We are additionally studying the potential host-microbe underpinnings of currently untreatable and unpredictable phenomena in IBD such as ileal fibrosis, peri-anal fistulae, extra-intestinal complications/manifestations that severely affect quality of life in these patients. To learn more, please visit the Devkota Lab.

The Postdoctoral Scientist will work independently but in close cooperation and in consultation with the Principal Investigator and other Research Scientist, the Research Fellow will perform routine and complex laboratory procedures throughout the training period. May develop, adapt, and implement new research techniques and protocols. Analyzes and interprets data. May assist in the preparation of grant proposals. Participates in publications and presentations as author or co-author. Not responsible for generating grant funds.

Primary Job Duties and Responsibilities:

--- May participate in publications and presentations as author or co-author.
--- Designs and performs experiments. Will keep appropriate experimental records and documentation and analyze the results with the Principal Investigator.
--- Analyzes interpret, summarizes, and compiles data.
--- Operates and maintains equipment and instruments.
--- May observe MD-patient or MD-human research subject interactions as it pertains directly to research being performed.

Department-Specific Duties:

--- Independently design experiments.
--- Perform animal surgeries and procedures as needed for projects.
--- Perform human tissue dissections.
--- Organize large numbers of clinical samples.
--- Maintain primary cell cultures from clinical specimens.
--- Isolate bacterial and total DNA and RNA from diverse sample types.
--- Cultivate live bacteria from tissues.
--- Prepare microbial DNA for qPCR and sequencing, and 16S rRNA sequencing analysis.
--- Perform host tissue analyses (ELISA, Western, PCR, qPCR, single-cell RNA-seq), ex vivo and in vitro immune assays.
--- Interact with collaborators.

Education:

--- Doctorate (MD, PhD, VMD, or DDS) in area directly related to field of research specialization, required.

Experience and Skills:

--- Acquires thorough technical and theoretical knowledge of research project and objectives during one to five (1-5) year post-doctoral appointment.
--- Works independently on research projects designed by a mentor (typically the PI) within area of specialization.
--- Demonstrated aptitude to perform experimental protocols and procedures, including detailed data collection, and analysis, and operation and maintenance of specialized equipment.
--- Knowledge of safety standards and maintenance of specialized equipment.

Working Title: Postdoctoral Scientist - Devkota Lab - Inflammatory Bowel Disease Institute
Department: Home Dept - Gastroenterology
Business Entity: Academic / Research
Job Category: Academic/Research
Job Specialty: Postdoctoral
Position Type: Full-time
Shift Length: 8 hour shift
Shift Type: Day
Base Pay:$64,500.00 - $93,600.00

Keywords: Cedars-Sinai, Beverly Hills , Postdoctoral Scientist - Devkota Lab - Inflammatory Bowel Disease Institute, Healthcare , Beverly Hills, California